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Tacrolimus(FK506)has recently been approved for immunosuppression in organ transplantation,although its use is accompanied by a wide spectrum of neurotoxic side effects.We describe the clinical,radiological,and pathological features of 3 cases of tacrolimus-related leukoencephalopathy.The syndrome of immunosuppression-related leukoencephalopathy is proposed as an uncommon neurological syndrome occurring in patients with organ transplants involving demyelination,in particular in the parieto-occipital region and centrum semiovale.Although the syndrome is not associated with a particular(absolute)serum level of tacrolimus,it resolves spontaneously upon decreasing the dose.The tacrolimus-related syndrome has a similar radiographic and pathologic appearance as the analogous syndrome that occurs in patients taking cyclosporine. |
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